Most people experience an occasional eyelid flutter, muscle cramp or post-workout spasm. These symptoms are usually temporary and often have common explanations such as fatigue, stress, exercise or dehydration. However, persistent and progressively worsening weakness, especially when it begins to interfere with movement, speech or everyday tasks, should be evaluated by a healthcare professional. Learn about the possible signs of amyotrophic lateral sclerosis, or ALS, and when to seek medical care.